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+12 Cytokine References . Cytokines are signaling proteins that help control inflammation in your body. Because cytokines are characterised by considerable redundancy and pleiotropism,. Cytokinemediated Bone Resorption in Rheumatoid Arthritis R&D Systems from www.rndsystems.com Numerous studies have implicated that inflammatory cytokines exert important effects with regard to various inflammatory diseases, yet the reports on their specific roles are not always consistent. Cytokines effect changes in cellular behaviour that are important in a number of physiological processes, including. Their physiologic role in inflammation and pathologic role in systemic inflammatory states are increasingly recognized.